کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502553 1557386 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ketal containing amphiphilic block copolymer micelles as pH-sensitive drug carriers
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Ketal containing amphiphilic block copolymer micelles as pH-sensitive drug carriers
چکیده انگلیسی

pH-Responsive linkages have been widely exploited in the development of polymeric drug delivery systems, which trigger drug release selectively at tumor tissues or endosomes and lysosomes of cells. Herein we report new pH-sensitive amphiphilic poly(ketal adipate)-co-poly(ethylene glycol) block copolymers (PKA-PEG), which have acid-cleavable ketal linkages in their hydrophobic backbone. PKA-PEG copolymers self-assemble to form stable micelles with a mean diameter of ~175 nm, which can encapsulate a payload of anticancer drugs and rapidly dissociate to release drug payload at the acid environment. The micelles are biocompatible and exhibit abilities to disrupt endosomes to enhance the cytosol drug delivery. Taken together, we anticipate that the pH-sensitive PKA-PEG micelles have great potential as anticancer drug carriers.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 448, Issue 1, 1 May 2013, Pages 259–266
نویسندگان
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