کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503161 1557420 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation
چکیده انگلیسی

Flavonoids have many positive effects on various cell layers of the skin (e.g. anti-oxidant, anti-allergic and anti-inflammatory effects). However, the limiting factor of the use of flavonoids is their low water solubility. To overcome the poor solubility, apigenin nanosuspensions were prepared using the combination technology (CT), i.e. bead milling and subsequently high pressure homogenization. Distinct reduction in particle size was observed after each bead milling passage resulting in z-average (PCS) of 413 nm and a polydispersity index of 0.202. The LD data showed a similar pattern of particle size reduction reaching a diameter 99% (d(v)99%) of 0.515 μm. The antioxidant capacity of apigenin nanocrystals were almost doubled compared to the original coarse suspension. The developed smartCrystals can be easily incorporated into gels, which makes apigenin nanocrystals available for dermal application as efficient antioxidant.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 420, Issue 1, 25 November 2011, Pages 133–140
نویسندگان
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