کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503357 1557432 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inulin and poly(acrylic acid) grafted inulin for dissolution enhancement and preliminary controlled release of poorly water-soluble Irbesartan drug
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Inulin and poly(acrylic acid) grafted inulin for dissolution enhancement and preliminary controlled release of poorly water-soluble Irbesartan drug
چکیده انگلیسی

In this article, inulin and poly(acrylic acid) grafted inulin copolymer were used to enhance the dissolution of poorly water-soluble Irbesartan drug and to control its drug release rate, respectively. Topological structure of inulin showed sleazy separable flower-like platelets and granules accumulated above each other, which adapt it to physically bind Irbesartan drug and enhance its dissolution. Consequently, the increase of inulin content in the polymeric matrix was found to increase the drug dissolution gradually until it reaches its maximum (∼90%) within the first 60 min. The release rate had followed zero-order transport mechanism. On the other hand, the poly(acrylic acid) grafted inulin copolymer, characterized using 1H NMR, FTIR, TGA, and SEM techniques, was found to form highly consistent amorphous systems of two-dimensional surfaces with some voids topology. Such features adapted it to control Irbesartan drug dissolution (∼33%) and show Fickian diffusion mechanism.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 410, Issues 1–2, 30 May 2011, Pages 206–211
نویسندگان
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