کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503587 1557433 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hollow porous implants filled with mesoporous silica particles as a two-stage antibiotic-eluting device
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Hollow porous implants filled with mesoporous silica particles as a two-stage antibiotic-eluting device
چکیده انگلیسی

A new type of implantable drug eluting device is presented, consisting of a bed of mesoporous microparticles packed inside a reservoir with a porous wall. This provides two sets of variables for drug release control that can be tailored independently. The first is related to the microparticles (packing density, size and pore structure) and the second to the reservoir (pore diameter and thickness of the wall, permeation area). In this work the concept is developed into a working model, used to fight bacterial (Staphylococcus aureus) growth by releasing linezolid that had previously been adsorbed on silica microparticles. These particles were placed inside the hollow interior of a porous medical grade stainless steel pin mimicking those used in traumatology and in orthopedic surgery. The mechanical behavior of the porous drug-eluting pin was tested and found satisfactory.

A new type of implantable drug eluting device is presented, consisting of a bed of porous sub-micron particles packed inside a reservoir with a porous wall acting as a two-stage antibiotic-eluting device.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 409, Issues 1–2, 16 May 2011, Pages 1–8
نویسندگان
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