کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503687 1557440 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations
چکیده انگلیسی

The objective of this study was to determine the effect of both carrier particle size and surface roughness on the aerosol performance of dry powder formulations. Two morphologically distinct grades of lactose, anhydrous (AN) and granulated (GR), were fractionated into 11 discreet sizes up to 300 μm, and separately employed as carriers in 2% (w/w) budesonide blends. In vitro deposition studies were performed at 60 L min−1 with an Aerolizer® DPI. It was found that large carriers can improve dispersion performance, although the effect is more pronounced with greater surface roughness. AN carriers exhibited minimal surface roughness and generally behaved as predicted from the literature, with the smaller carriers outperforming their larger counterparts. In contrast, GR carriers had a high degree of surface roughness, and the dispersion performance of larger carriers exceeded that of the smaller size fractions. Comparing the two lactose grades, AN carriers deposited a greater fraction of the total dose up to the 90–125 μm size range, when they were surpassed in performance by the GR carriers. These results suggest that the mechanism of drug detachment varies with the physical properties of the carrier particle population, where surface roughness can alter the predominant detachment mechanism to favor larger carrier particle diameters.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 402, Issues 1–2, 15 December 2010, Pages 1–9
نویسندگان
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