کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2503691 | 1557440 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and study of controlled release of ofloxacin from polyester conjugates Synthesis and study of controlled release of ofloxacin from polyester conjugates](/preview/png/2503691.png)
New polymeric conjugates were prepared coupling ofloxacin to two-, three-, four and six-arm, star-shaped poly(ɛ-caprolactone) and polylactide. The homopolymers were synthesized via ring-opening polymerization of ɛ-caprolactone, l-lactide and rac-lactide in the presence of glycerol, penthaerythritol, dipentaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. The conjugates were characterized by GPC, MALDI-TOF MS, NMR, IR and viscosity methods. Content of Sn has been investigated in polymers by electrothermal atomic absorption spectrometry. Toxicity of monomers, initiators and polymers were evaluated with bacterial luminescence test and two protozoan assays. The in vitro release of ofloxacin from obtained conjugates in pH 7 was investigated.
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Journal: International Journal of Pharmaceutics - Volume 402, Issues 1–2, 15 December 2010, Pages 37–43