کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503827 1557445 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determining the coating thickness of tablets by chiseling and image analysis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Determining the coating thickness of tablets by chiseling and image analysis
چکیده انگلیسی

Several tablets are chiseled and imaged in order to determine the variation in the coating thickness with the addition of the coating material (weight-gain). Chiseling is carried out with an ultrasonic chisel. The chiseled tablets are imaged in full and these images are exported into programming language Matlab in order to numerically analyze all the pixels along one side of the tablet. The coating thickness is statistically assessed at four cutting depths for three tablets obtained from four weight-gain experiments, a total of 48 images. The coating layer is clearly visible and determinable in the ‘white-light’ images even for the smallest weight gain of 1% but with sizeable errors due to the diffused boundaries between the coating and the core on one, and the coating and the background on the other side. Addition of the coating material clearly increases the coating thickness which is found to be somewhat higher at the top of the tablets than at the edges. Two approaches for assessment of the coating thickness are tested and are found to be in a very good agreement except for the thinnest coating layer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 397, Issues 1–2, 15 September 2010, Pages 109–115
نویسندگان
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