کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503962 1557447 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon
چکیده انگلیسی

Delivery of drugs by the oral route remains the most spread route to administer medicines to patients. The manuscript takes into consideration the most important organs of the digestive system (mouth, oesophagus, stomach, small intestine and colon), their size, physiology and transit patterns of dosage forms while travelling in the digestive tract. For each organ several strategies are considered, namely, adhesion, chemical modification of drug and/or excipient moieties, technological features of dosage forms (e.g. porosity, disintegration time), pH variations or transit times. The manuscript considers strategies that are commonly used in practice for long-term administration of drugs, without interfering with human physiology, and feasible industrially.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 395, Issues 1–2, 16 August 2010, Pages 44–52
نویسندگان
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