کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2504468 | 1557461 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of ofloxacin–oxalic acid complex by PXRD, NMR, and THz spectroscopy
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of ofloxacin–oxalic acid complex by PXRD, NMR, and THz spectroscopy Characterization of ofloxacin–oxalic acid complex by PXRD, NMR, and THz spectroscopy](/preview/png/2504468.png)
چکیده انگلیسی
A novel ofloxacin–oxalic acid complex was prepared by the cogrinding method. The obtained complex was characterized by powder X-ray diffraction (PXRD), infrared (IR), solid-state nuclear magnetic resonance (NMR), and terahertz (THz) spectroscopy. The PXRD measurement revealed that the ofloxacin–oxalic acid complex induced by cogrinding was formed at a molar ratio of 1:2. Weak interaction between two components, not a hydrogen bonding, was found by IR and solid-state NMR spectroscopy. The distinctive THz spectrum showed that the vibrational modes of the complex were different from those of the starting materials, suggesting that THz spectroscopy is an alternative tool to evaluate complex formation through weak interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 382, Issues 1–2, 1 December 2009, Pages 50–55
Journal: International Journal of Pharmaceutics - Volume 382, Issues 1–2, 1 December 2009, Pages 50–55
نویسندگان
Waree Limwikrant, Kenjirou Higashi, Keiji Yamamoto, Kunikazu Moribe,