کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504475 1557461 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyisoprene matrix for progesterone release: In vitro and in vivo studies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Polyisoprene matrix for progesterone release: In vitro and in vivo studies
چکیده انگلیسی

Latex, a polyisoprene (PI) hydrophobic elastomer, was evaluated in vitro and in vivo as a matrix for intravaginal steroid hormone delivery. Matrices containing hormone were prepared by swelling latex in chloroform that contained soluble progesterone (P4). In vitro studies demonstrate that P4 release from PI follows a zero order model during at least 100 h and depends on initial load up to 10 mg cm−2. The release of P4 from a PI matrix was found to be two times faster than from a polydimethylsiloxane (PDMS) matrix. FT-IR and X-ray powder diffraction analysis of P4 polymorphs show that when nucleated in PDMS, the hormone crystallizes only in α-form while in latex, crystallizes as a mixture of α- and β-form. In vivo studies show that devices with a PI matrix containing 0.5 g of P4 are effective to reach plasma levels above 1 ng ml−1 that are needed to synchronize estrous in cattle. Altogether, the results show that PI, a vulcanized polymer with a carbon–carbon backbone, can be used as a new matrix for the intravaginal administration of progesterone with improved release profile than silicone and that the matrix can influence the crystalline state of the hormone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 382, Issues 1–2, 1 December 2009, Pages 98–103
نویسندگان
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