کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504522 1557457 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new sol–gel silica nanovehicle preparation for photodynamic therapy in vitro
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
A new sol–gel silica nanovehicle preparation for photodynamic therapy in vitro
چکیده انگلیسی

We report a facile silica nanovehicle preparation procedure for hydrophobic drug delivery, which is carried out in water without adding any surfactant and additional catalyst. This strategy includes hydrophobic drug nanopaticle preparation by reprecipitation method and in situ hydrolyzation and polymerization to encapsulate this naoparticle using only N-(β-amimoethyl)-γ-aminopropyltyiethoxysilane (AETPS). To demonstrate this technique hypocrellin A (HA), a hydrophobic photosensitizing anticancer drug, is embedded into silica nanovehicle using this simple method. The resulting HA encapsulated nanovehicles (HANV) are monodisperse and stable in aqueous solution. Comparative studies with free HA and entrapped HA have demonstrated that the encapsulation effect on the embedded photosensitizer nanoparticle significantly enhances the efficacy of singlet oxygen generation and, thereby, the in vitro photodynamic efficacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 386, Issues 1–2, 15 February 2010, Pages 131–137
نویسندگان
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