Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation

This study aimed to develop a stable solid dispersion of Coenzyme Q10 (CoQ10) with high aqueous solubility and dissolution rate. Among various carriers screened, poloxamer 407 was most effective to form a superior solid dispersion of CoQ10 having significantly enhanced solubility. Particularly, solid dispersion of CoQ10 with poloxamer 407 in the weight ratio of 1:5 prepared by melting method enhanced the solubility of CoQ10 to the greatest extent. However, it exhibited poor stability and hence Aerosil® 200 (colloidal silicon dioxide) was incorporated into the solid dispersion as an adsorbent to inhibit the recrystallization process. The solid dispersion of CoQ10, poloxamer 407 and Aerosil® 200 in the weight ratio of 1:5:6 exhibited improved stability with no significant change in solubility during the 1-month stability test. Moreover, the solid dispersion formulation containing Aerosil® 200 significantly enhanced the extent of drug release (approx. 75% release) as well as the dissolution rate of CoQ10. In conclusion, the present study has developed the stable solid dispersion formulation of CoQ10 with poloxamer 407 and Aerosil® 200 for the enhanced solubility and dissolution of CoQ10, which could also offer some additional advantages including ease of preparation, good flowability and cost-effectiveness.