کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505347 1557487 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chitosan–carboxymethylcellulose interpolymer complexes for gastric-specific delivery of clarithromycin
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Chitosan–carboxymethylcellulose interpolymer complexes for gastric-specific delivery of clarithromycin
چکیده انگلیسی

Chitosan (CS) and carboxymethylcellulose (CMC) sodium interpolymer complexes were formed using the novel method “tablets-in-capsule” for stomach drug delivery. The aim of this study was to investigate the influence of the molecular weight (M.wt.) of CS and the proportion CS/CMC on physical properties and clarithromycin (CAM) release.Swelling was dependent on CS M.wt., on medium pH and on proportion polymer/polymer. The higher M.wt., the major presence of protonated amined moieties that can be ionized and modify the swelling/eroding and dissolution medium uptake capacity. Swelling kinetics at pH 1.2, were close to Fickian diffusion, whereas at pH 4.2 were non-Fickian. Furthermore, dissolution medium uptake capacity can be adjusted to an exponential equation at pH 1.2 (r2 ≥ 0.96), and to a linear equation at pH 4.2 (r2 ≥ 0.99), showing that at low pHs the repulsion among ionized chains is higher.CAM release rates have shown to be dependent on pH and on polymer proportion. At pH 1.2, the fastest profile was obtained when using high M.wt. CS. Drug diffusion was Fickian, so the process is governed by swelling/eroding. Whereas at pH 4.2, CAM release followed zero-order kinetics with no influence on M.wt. So, release is controlled by CAM low solubility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 359, Issues 1–2, 9 July 2008, Pages 135–143
نویسندگان
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