کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2505579 | 1557491 | 2008 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Evaluation of solid state properties of solid dispersions prepared by hot-melt extrusion and solvent co-precipitation Evaluation of solid state properties of solid dispersions prepared by hot-melt extrusion and solvent co-precipitation](/preview/png/2505579.png)
The solid state properties of solid dispersions of Compound A in hypromellose acetate succinate (HPMC-AS) prepared by hot-melt extrusion (HME) and solvent co-precipitation (CP) processes were evaluated using powder X-ray diffractometry (PXRD), thermal analysis, optical microscopy, scanning electron microscopy (SEM), FT-IR and Raman spectroscopy, water vapor sorption analyzer, and surface area by BET. PXRD indicated that both processes converted the crystalline drug into amorphous solid dispersions with a glass transition temperature around 104–107 °C and both products have similar spectroscopic and hygroscopic properties. The two products have similar true densities; however, the CP product is more porous and has a larger specific surface area than the HME product, as indicated by the BET results and SEM micrographs. Dissolution study using USP apparatus 2 showed that the CP product had a faster dissolution profile, but slower intrinsic dissolution rate than the HME product. The two products have acceptable physical stability after storage in 40 °C/75% RH chamber for 3 months. However, the HME product is more stable than the CP product in aqueous suspension formulation.
Journal: International Journal of Pharmaceutics - Volume 355, Issues 1–2, 1 May 2008, Pages 141–149