کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2505693 | 1557496 | 2008 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: How to achieve sustained and complete protein release from PLGA-based microparticles? How to achieve sustained and complete protein release from PLGA-based microparticles?](/preview/png/2505693.png)
One of the most challenging tasks in the delivery of therapeutic proteins from PLGA-based microparticles is the sustained and complete release of the protein in its native form. The mechanisms responsible for incomplete protein release from these devices are numerous and complex; the beneficial effect of different formulations has often been evaluated in vitro. Strategies employed for overcoming protein destabilization during the release step are reviewed in this paper. Proteins have been protected in the deleterious environment by adding stabilizers to the formulation, or by modifying the protein or the polymer. Alternatively, some strategies have aimed at avoiding the formation of the destabilizing environment. As experimental conditions may influence the results from in vitro release studies, we initially report precautions to avoid adverse effects.
Journal: International Journal of Pharmaceutics - Volume 350, Issues 1–2, 28 February 2008, Pages 14–26