کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505823 1557497 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation
چکیده انگلیسی

Rapamycin-loaded chitosan/polylactic acid nanoparticles with size of about 300 nm in diameter were prepared through nanoprecipitation method using cholesterol-modified chitosan as a stabilizer. The surface coating of chitosan, which was demonstrated by zeta potential measurement, endowed the nanoparticles good retention ability at the procorneal area, facilitating the sustained release of rapamycin on the corneal. The immunosuppression in corneal transplantation of the nanoparticles was investigated using rabbit as animal model, the median survival time of the corneal allografts treated with nanoparticles was 27.2 ± 1.03 days and 50% grafts still remained surviving by the end of the observation, while the group treated with 0.5% rapamycin suspension was 23.7 ± 3.20 days. The median survival time of drug-free nanoparticles group and untreated groups were 10.9 ± 1.45 and 10.6 ± 1.26 days, respectively. The results demonstrated the excellent immunosuppression of rapamycin-loaded chitosan/polylactic acid nanoparticles in corneal transplantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 349, Issues 1–2, 12 February 2008, Pages 241–248
نویسندگان
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