کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506361 1557518 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Morphology control of polylactide microspheres enclosing irinotecan hydrochloride with polylactide based polymer surfactant for reduction of initial burst
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Morphology control of polylactide microspheres enclosing irinotecan hydrochloride with polylactide based polymer surfactant for reduction of initial burst
چکیده انگلیسی

We introduced newly biodegradable polymer surfactant to poly(d,l-lactide) microspheres for exhibiting precisely controlled release rate of antitumor agent. We newly designed biodegradable polymer surfactant, poly(ethyleneoxide monooleate)-block-poly(d,l-lactide); (MOPEO-PLA), which has a biocompatible, oil-soluble and compatible with polylactide matrices. Polylactide (PLA) microspheres with MOPEO-PLA enclosing Irinotecan hydrochloride (CPT-11) was successfully fabricated by solvent evaporation method via O/O emulsion. The surface morphology was strongly affected to MOPEO-PLA content in PLA microspheres; the wrinkles on microsphere surface were decreased with increasing MOPEO-PLA content. It was found from DSC scans that Tg of PLA drastically decreased with introducing MOPEO-PLA, indicating that MOPEO-PLA miscible with PLA. MOPEO-PLA, played as a plasticizer, made the surface smoothed. The rate of release in a short duration was minimum value at adding 20 wt.% of MOPEO-PLA. This result was due to the smaller surface area of PLA microspheres with smoothed surface.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 330, Issues 1–2, 7 February 2007, Pages 32–36
نویسندگان
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