کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506369 | 1557518 | 2007 | 6 صفحه PDF | دانلود رایگان |
The aims of this study were to compare the properties of granules prepared in a high-shear granulator and dried by using different methods (fluid-bed and microwave-vacuum drying) and to compare the properties of tablets pressed from such granules. Experiments on a production scale were performed with Collette Ultima Pro 600 single-pot processing equipment and a Glatt WSG 200 fluid-bed granulator and drier. The particles granulated in the traditional high-shear granulator and dried in a vacuum chamber had a higher porosity and higher bulk and tapped densities, as a consequence of the special characteristics of the drying process. They retained their spherical form, in contrast with the particles dried via the fluid-bed technology. The two types of granules required different compressing forces for tabletting.
Journal: International Journal of Pharmaceutics - Volume 330, Issues 1–2, 7 February 2007, Pages 99–104