کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506400 1557513 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studying thermodynamic aspects of sublimation, solubility and solvation processes and crystal structure analysis of some sulfonamides
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Studying thermodynamic aspects of sublimation, solubility and solvation processes and crystal structure analysis of some sulfonamides
چکیده انگلیسی

Crystal structures of N-(2-chlorophenyl)-benzene-sulfonamide (I), N-(2,3-dichlorophenyl)-benzene-sulfonamide (II), N-(4-chlorophenyl)-benzene-sulfonamide (III) were solved by X-ray diffraction method. Temperature dependencies of saturated vapor pressure and thermodynamic functions of sublimation process were calculated (I: ΔGsub298=50.4 kJ mol−1; ΔHsub298=114±1 kJ mol−1; ΔSsub298=213±3 J mol−1 K−1; II: ΔGsub298=54.1 kJ mol−1; ΔHsub298=124.9±1.6 kJ mol−1; ΔSsub298=237±5 J mol−1 K−1; III: ΔGsub298=49.9 kJ mol−1; ΔHsub298=98.6±1.9 kJ mol−1; ΔSsub298=163±5 J mol−1 K−1). Thermochemical parameters of fusion process for the compounds were obtained. Enthalpies of evaporation were estimated from enthalpies of sublimation and fusion. Temperature dependencies of the solubility in water, n-octanol and n-hexane were measured. The thermodynamic functions of solubility and solvation processes were deduced. Specific and non-specific solvation terms were distinguished using the transfer from the “inert” n-hexane to the other solvents. The transfer processes of the molecules from water to n-octanol were analyzed and main driven forces were established.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 334, Issues 1–2, 4 April 2007, Pages 115–124
نویسندگان
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