کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506436 1557514 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Integrity of liposomes in presence of cyclodextrins: Effect of liposome type and lipid composition
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Integrity of liposomes in presence of cyclodextrins: Effect of liposome type and lipid composition
چکیده انگلیسی

Liposome stability during incubation in presence of cyclodextrins (CDs) is studied. Dried-rehydrated vesicle (DRV), multilamellar vesicle (MLV) and small unilamellar vesicle (SUV) calcein-encapsulating liposomes, composed of different lipids are formulated, and retention of calcein is followed during vesicle incubation in hydroxypropyl-β-CD (HPβ-CD), HPγ-CD or methyl-β-CD (Meβ-CD), for 24 h. Results demonstrate that liposome integrity in cyclodextrins is affected by lipid composition and type. For the same lipid composition calcein release from vesicles is faster in the order: MLV > DRV > SUV. Meβ-CD influences liposome stability most, compared to the other CD's studied. Vesicles composed of saturated phospholipids were found more stable compared to phosphatidyl-choline (PC) liposomes, suggesting that phospholipid saturation and membrane rigidity influences the interaction between liposomal-lipids and CD molecules. Chol (cholesterol) addition in lipid membrane improves PC-liposome integrity, but has opposite or no effect on liposomes consisting of saturated lipids.Decrease of vesicle dispersion turbidity and size distribution in presence of CD, implies that Meβ-CD induces vesicle disruption and solubilization (to micelles). Turbidity measurements confirm that DRV liposomes are affected more than SUV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 333, Issues 1–2, 21 March 2007, Pages 167–176
نویسندگان
, , , ,