کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506528 1557519 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced immune responses induced by vaccine using Sendai virosomes as carrier
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Enhanced immune responses induced by vaccine using Sendai virosomes as carrier
چکیده انگلیسی

Sendai virosomes can deliver encapsulated contents into the cytoplasm directly in a virus fusion-dependent manner. In this paper, Sendai virosomes-formulated melanoma vaccine was constructed and its anti-tumor effects were investigated. The melanoma vaccine was prepared by encapsulating mixture antigen into the Sendai virosomes. The antigen, mixture proteins were extracted from B16 melanoma cells. The cytotoxic T lymphocyte (CTL) response level was evaluated by 51Cr release method, and the change of CD4+ and CD8+ expression as well as the concentration of IgG in serum of immunized mice was measured. The results showed that Sendai virosomes-formulated melanoma vaccine can effectively elicit not only systemic immune response but also strong CTL response. Sendai virosomes can be used as an effective vector for use in anti-tumor vaccine therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 329, Issues 1–2, 1 February 2007, Pages 117–121
نویسندگان
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