کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506554 | 1557523 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Solid state characterization of olanzapine polymorphs using vibrational spectroscopy Solid state characterization of olanzapine polymorphs using vibrational spectroscopy](/preview/png/2506554.png)
FT-Raman, infrared and near infrared investigations of two polymorphs of olanzapine are presented, establishing the main features that allow the discrimination of these crystalline forms using vibrational spectroscopic methods. Ab initio calculations on the basis of the density functional theory were used to determine the stable conformations. The calculated vibrational spectra were compared to the experimental ones in order to identify the conformers corresponding to each polymorph and to assign the vibrational bands to the internal vibrations of the olanzapine molecule. Our results support the hydrogen bonding pattern proposed by the reported crystalline structure and provide valuable information on the structural and thermodynamical relationship between the investigated polymorphs.
Journal: International Journal of Pharmaceutics - Volume 326, Issues 1–2, 1 December 2006, Pages 69–79