کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506587 | 1557526 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced antisense effect of modified PNAs delivered through functional PMMA microspheres
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Peptide nucleic acids (PNA) are very promising antisense agents, but their in vivo application is often hampered by their low bioavailability, mainly due to their limited uptake through cellular and nuclear membranes. However, PNA chemical synthesis easily allows modification with functional structures able to improve the intrinsically low permeability and great interest is arising in finding specific and efficient delivery protocols. Polymeric core-shell microspheres with anionic functional groups on the surface were tested for their ability to reversibly bind lysine modified PNA sequences, whose antisense activity against COX-2 mRNA was already demonstrated in murine macrophages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 324, Issue 1, 31 October 2006, Pages 83–91
Journal: International Journal of Pharmaceutics - Volume 324, Issue 1, 31 October 2006, Pages 83–91
نویسندگان
Laura Chiarantini, Aurora Cerasi, Enrico Millo, Katia Sparnacci, Michele Laus, Massimo Riccio, Spartaco Santi, Marco Ballestri, Silvia Spaccasassi, Luisa Tondelli,