کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506666 | 1557521 | 2007 | 6 صفحه PDF | دانلود رایگان |
The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved.SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 μm were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 °C, 100 bar, 1 mL min−1 liquid flow and 10 L min−1 carbon dioxide flow.Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased.
Journal: International Journal of Pharmaceutics - Volume 328, Issue 1, 2 January 2007, Pages 72–77