کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506720 | 1557528 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new copolymer membrane controlling clonidine linear release in a transdermal drug delivery system
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
A new type of copolymer membranes was prepared through photosynthesis of mixtures of three different monomers. The membranes present a linear permeation property in clonidine transdermal drug delivery system. Monomers used in the photosynthesis were 2-hydroxy-3-phenoxypropylacrylate, 4-hydroxybutyl acrylate and sec-butyl tiglate. Permeation property of the membranes with different monomer ratios and thickness were investigated. When clonidine concentrations were in 3.0–5.0 mg/ml range, membranes showed near zero order permeation rates. An optimized membrane was characterized by FTIR, DSC and SEM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 322, Issues 1–2, 28 September 2006, Pages 1–5
Journal: International Journal of Pharmaceutics - Volume 322, Issues 1–2, 28 September 2006, Pages 1–5
نویسندگان
Xiaoping Zhan, Guochun Tang, Sijing Chen, Zhenmin Mao,