کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2506804 1557531 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-state properties and crystallization behavior of PHA-739521 polymorphs
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Solid-state properties and crystallization behavior of PHA-739521 polymorphs
چکیده انگلیسی

PHA-739521 is an experimental compound that exhibits polymorphism. The two anhydrous crystal forms, I and II, are characterized using powder X-ray diffractometry, thermal analyses, moisture sorption gravimetry. Both Forms I and II are non-hygroscopic and are stable to compaction pressure. The melting temperature is about 152 °C for Form I and 168 °C for Form II. Forms I and II are enantiotropically related where Form I is more stable below a transition temperature of approximately 70 °C. Crystallization behavior of this compound from solutions and during heating is also studied. Information obtained is used to design an appropriate crystallization process to successfully manufacture desired polymorph at large scale.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 319, Issues 1–2, 17 August 2006, Pages 114–120
نویسندگان
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