کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506867 | 1557539 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Metolose–PEG interaction as seen by positron annihilation spectroscopy Metolose–PEG interaction as seen by positron annihilation spectroscopy](/preview/png/2506867.png)
The plasticizing effects of poly(ethylene glycol) (PEG 400) on methylcellulose (Metolose) cast films were studied by conventional physicochemical methods and positron annihilation spectroscopy. The PEG concentrations relative to the total polymer content were varied within the range 0–75% (w/w). At low concentrations (below 33.3%, w/w), the plasticizer was found to build in into the methylcellulose structure. On the other hand, at higher concentrations (above 50%, w/w), it formed small separate phases in the films.Positron annihilation spectroscopy (PALS) was applied to track the Metolose–PEG interaction. Controlled ageing of Metolose–PEG films at room temperature and at 75% RH revealed a significant difference between the ageing processes of the monophase and those of the separate phase films. The ageing involves two steps in both cases: a fast and a slow one. The PALS measurements demonstrated that the slow process is hindered in the phase-separated samples.
Journal: International Journal of Pharmaceutics - Volume 313, Issues 1–2, 26 April 2006, Pages 66–71