کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2506878 | 1557539 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Oral delivery of diclofenac sodium using a novel solid-in-oil suspension Oral delivery of diclofenac sodium using a novel solid-in-oil suspension](/preview/png/2506878.png)
The present work reports on a new pharmaceutical formulation for oral delivery of diclofenac sodium (DFNa), a non-steroidal anti-inflammatory drug (NSAID). Although DFNa itself is water-soluble at neutral pH, it was readily suspended in soybean oil via complex formation with an edible lipophilic surfactant and a matrix protein. The resulting solid-in-oil (S/O) suspension containing stably encapsulated DFNa in an oil phase markedly reduced the risks for gastrointestinal ulcers upon oral administration even at the LD50 level in rats (ca. 50 mg/kg DFNa). In addition, plasma concentration of DFNa upon administration of an S/O suspension was comparable with that of the aqueous counterpart at the same DFNa dose. These results indicate the potential use of S/O suspensions as novel oil-based pharmaceutical formulations for oral delivery of water-soluble drugs without causing severe mucitis.
Journal: International Journal of Pharmaceutics - Volume 313, Issues 1–2, 26 April 2006, Pages 159–162