کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507789 1117508 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combined collision-induced dissociation and photo-selected reaction monitoring mass spectrometry modes for simultaneous analysis of coagulation factors and estrogens
ترجمه فارسی عنوان
تلفات ناشی از برخورد ناشی از انفجار و انتخاب عکس انتخاب شده واکنش های جرم طیف سنجی برای تجزیه و تحلیل همزمان عوامل فاکتور انعقادی و استروژن
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Oral estrogens are directly associated with changes in plasma levels of coagulation proteins. Thus, the detection of any variation in protein concentrations due to estrogen contraceptives, by a simultaneous analysis of both coagulation proteins and estrogens, would be a very informative tool. In the present study, the merit of photo-selected reaction monitoring (SRM), a new analytical tool, was evaluated towards estrogens detection in plasma. Then, SRM and photo-SRM detection modes were combined for the simultaneous analysis of estrogen molecules together with heparin co-factor and factor XIIa, two proteins involved in the coagulation cascade. This study shows that photo-SRM could open new multiplexed analytical routes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Analysis - Volume 4, Issue 3, June 2014, Pages 183–189
نویسندگان
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