کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507880 1117514 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and validation of the stability-indicating LC–UV method for the determination of Cefditoren pivoxil
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Development and validation of the stability-indicating LC–UV method for the determination of Cefditoren pivoxil
چکیده انگلیسی

An isocratic RP-HPLC method was developed for the determination of Cefditoren pivoxil in pharmaceutical formulations using a C-18 column with water–acetonitrile (50:50, v/v) as mobile phase and flow rate 1.2 mL/min (UV detection at 218 nm). Linearity was observed in the concentration range 1.0–250 μg/mL (R2=0.999) with regression equation y=24194x+10749. The forced degradation studies were performed by using HCl, NaOH, and H2O2, and thermal and UV radiation. Cefditoren pivoxil is more sensitive towards oxidation and alkaline conditions and resistant towards acidic and photolytic degradations. The method was validated as per ICH guidelines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Analysis - Volume 2, Issue 6, December 2012, Pages 466–469
نویسندگان
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