کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2507903 1117516 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME–LC–MS analysis
چکیده انگلیسی

A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Analysis - Volume 4, Issue 1, February 2014, Pages 6–13
نویسندگان
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