Antibody-based concepts for multipurpose prevention technologies

• Antibodies are specific and versatile candidates for multipurpose prevention technologies.
• Low cost and scaleable manufacturing is required to complement Ab versatility.
• Antibodies can be formulated as topicals (gel, film, device), injectables, and vaccines.

Because of the versatility and specificity of monoclonal antibodies, they are candidates for multipurpose prevention technologies when formulated as topical (gels, films, rings) or injectable drugs and as vaccines. This review focuses on antibody-based proof of concept studies for the human immunodeficiency virus, herpes simplex virus and sperm. Opportunities and challenges in antibody evasion/resistance, manufacturing, regulatory, and pharmacoeconomics are discussed. This article is based on a presentation at the “Product Development Workshop 2013: HIV and Multipurpose Prevention Technologies,” held in Arlington, Virginia on February 21–22, 2013. It forms part of a special supplement to Antiviral Research.