کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2510703 | 1117981 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Development of a broad-spectrum antiviral with activity against Ebola virus Development of a broad-spectrum antiviral with activity against Ebola virus](/preview/png/2510703.png)
We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift Valley and Dengue Fever viruses, in cell-based assays. Using mouse models of Ebola virus, we further demonstrate that FGI-106 can protect animals from an otherwise lethal infection when used either in a prophylactic or therapeutic setting. A single treatment, administered 1 day after infection, is sufficient to protect animals from lethal Ebola virus challenge. Cell-based assays also identified inhibitory activity against divergent virus families, which supports a hypothesis that FGI-106 interferes with a common pathway utilized by different viruses. These findings suggest FGI-106 may provide an opportunity for targeting viral diseases.
Journal: Antiviral Research - Volume 83, Issue 3, September 2009, Pages 245–251