کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2512310 1118337 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Merging old and new perspectives on nicotinic acetylcholine receptors
ترجمه فارسی عنوان
ادغام دیدگاه های قدیمی و جدید در گیرنده های استیل کولین نیکوتین
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

This review covers history underlying the discovery of the molecular mediators of nicotine's effects in the brain and the diversity of the nicotinic acetylcholine receptor (nAChR) subtypes. Models are presented for both their structure and their function as mediators of signal transduction, with special consideration of the differences between the two main subtypes: heteromeric receptors, which are specialized for rapid electrochemical signal transduction, and homomeric α7 receptors, which have come to be implicated in both ionotropic and metabotropic signaling. This review presents perspectives on the pharmacology and therapeutic targeting of nAChRs for the treatment of nicotine dependence or disease.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 89, Issue 1, 1 May 2014, Pages 1–11
نویسندگان
,