کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2515097 | 1118500 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Epigenetic silencing of MHC2TA transcription in cancer Epigenetic silencing of MHC2TA transcription in cancer](/preview/png/2515097.png)
Lack of expression of major histocompatibility complex (MHC) molecules of both classes is frequently noted on tumour cells [1]. It is thought that in this way tumour cells escape immunosurveillance. The genes encoding both classes of MHC molecules are localized on the distal part of chromosome 6 (6p21.3). The class II transactivator (CIITA), encoded by the MHC2TA gene, is essential for transcriptional activation of all MHC-II genes, while it has a helper function in the transcriptional regulation of MHC-I genes (with the exception of human leukocyte antigen (HLA)-G) and of the gene encoding β2-microglobulin (β2m) [2]. Here we discuss our current knowledge on the expression characteristics of MHC2TA and argue for an important role of epigenetic factors and mechanisms in the transcriptional silencing of MHC2TA in cancer cells.
Journal: Biochemical Pharmacology - Volume 72, Issue 11, 30 November 2006, Pages 1570–1576