کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2525798 1119633 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative cytoprotective activity of vitamin C, E and beta-carotene against chromium induced oxidative stress in murine macrophages
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Comparative cytoprotective activity of vitamin C, E and beta-carotene against chromium induced oxidative stress in murine macrophages
چکیده انگلیسی

The present study reports the cytoprotective efficacy of vitamin C, E and beta-carotene against chromium (VI) induced oxidative stress in murine macrophages. Addition of chromium (VI) resulted in enhanced cytotoxicity as revealed by fall in neutral red uptake and increase in LDH release compared to control cells. Further there was an appreciable increase in apoptosis, ROS production and fall in reduced glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities. Chromium also inhibited macrophage proliferation and phagocytic activity. Addition of vitamin C but not vitamin E and beta-carotene inhibited chromium induced cytotoxicity, ROS generation and apoptosis. Vitamin C significantly inhibited NO production, enhanced macrophage proliferation and phagocytic activity while vitamin E and beta-carotene had marginal effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 60, Issue 2, February 2006, Pages 71–76
نویسندگان
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