کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2526039 1119667 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular and pharmacodynamic characteristics of the novel multi-target tumor growth inhibitor ZK 304709
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Molecular and pharmacodynamic characteristics of the novel multi-target tumor growth inhibitor ZK 304709
چکیده انگلیسی

Loss of cell cycle control and tumor-induced neovascularization are major drivers of human tumor growth. The multi-target tumor growth inhibitor ZK 304709 is a nanomolar inhibitor of cyclin-dependent kinases 1, 2, 4, 7 and 9, as well as vascular endothelial growth factor receptor tyrosine kinase 1–3 and of platelet-derived growth factor receptor β tyrosine kinase. The multi-targeted mode of action of ZK 304709 acting on cell cycle and angiogenesis resulted in superior efficacy compared to standard chemotherapeutic compounds both in s.c. human tumor xenografts as well as orthotopic human pancreatic carcinoma models.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 60, Issue 6, July 2006, Pages 269–272
نویسندگان
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