Estrogen dependence of the renal vasodilatory effect of nicotine in rats: Role of α7 nicotinic cholinergic receptor/eNOS signaling

Estrogen-dependent facilitation of NOS signaling mediates the enhanced vasodilator capacity of nicotine in the renal vasculature of female rats. Preliminary evidence also suggests a potential role for α7 nAChRs in this estrogen-dependent phenomenon.