کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2551985 1560696 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neonatal nicotine exposure alters leptin signaling in the hypothalamus–pituitary–thyroid axis in the late postnatal period and adulthood in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Neonatal nicotine exposure alters leptin signaling in the hypothalamus–pituitary–thyroid axis in the late postnatal period and adulthood in rats
چکیده انگلیسی

AimsPostnatal nicotine exposure causes precocious primary hypothyroidism and programs for overweight, hyperleptinemia and secondary hypothyroidism in adulthood. As leptin and thyroid hormones share the ability to increase energy expenditure, we studied the effects of maternal nicotine exposure during lactation on the leptin signaling in the hypothalamus–pituitary–thyroid axis of suckling and adult offspring.Main methodsTwo days after delivery, osmotic minipumps were implanted in lactating rats, and nicotine (NIC, 6 mg/kg/day s.c.) or saline (C) was administered for 14 days. Offspring were killed at 15 and 180 days-old. Proteins belonging to leptin signaling were analyzed by Western blot. Significant differences had p < 0.05.Key findingsIn the hypothalamus, NIC offspring showed higher OB-R and pSTAT-3 content (+ 58%,+1.34x) at 15 days, and lower OB-R, JAK-2 and pSTAT-3 (−61%, −42%, −56%) at 180 days. In the pituitary gland, NIC offspring showed lower JAK-2 content (−52%) at 15 days, but no differences in adulthood. In the thyroid gland, the NIC group presented lower OB-R, JAK-2 and STAT-3 (−44%, −50%, −47%) and higher pSTAT-3 expression (+ 80%) at 15 days. At 180 days-old, NIC offspring presented higher thyroid OB-R (+ 1.54x) and lower pSTAT-3 content (−34%).SignificanceNeonatal primary hypothyroidism induced by maternal nicotine exposure during lactation may be partially explained by decreased leptin signaling in the thyroid, though the early stimulation of the central leptin pathway did not prevent the thyroid dysfunction. Long-term effects of postnatal nicotine exposure on leptin signaling in the hypothalamus and thyroid appear to involve central and peripheral leptin resistance in adulthood.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 87, Issues 5–6, 31 July 2010, Pages 187–195
نویسندگان
, , , , , , , ,