کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2552987 | 1124875 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits](/preview/png/2552987.png)
Previously, we reported that a relatively selective adenosine A2A receptor agonist 2-(6-cyano-1-hexyn-1-yl)adenosine (2-CN-Ado) elicited ocular hypotension in rabbits (Journal of Pharmacological Sciences 2005;97:501–509). In the present study, we investigated the effect of 2-CN-Ado on ocular blood flow in rabbit eyes. An intravitreal injection of 2-CN-Ado increased ocular blood flow, measured by a non-contact laser flowmeter. 2-CN-Ado-induced increase in ocular blood flow was accompanied with the retinal vasodilation. The increase in ocular blood flow was inhibited by an adenosine A2A receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine, but not by an adenosine A2B receptor antagonist alloxazine or an adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine. The repetitive applications of topical 2-CN-Ado twice a day for 7 days produced a persistent increase in ocular blood flow with ocular hypotension. These results suggest that 2-CN-Ado increases the ocular blood flow mainly via adenosine A2A receptor, and that the topical application of 2-CN-Ado for several days not only increases the ocular blood flow but also prolong ocular hypotension, indicating that 2-CN-Ado may be a useful lead compound for the treatment of ischemic retinal diseases such as glaucoma.
Journal: Life Sciences - Volume 80, Issue 12, 27 February 2007, Pages 1115–1122