کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2553744 | 1124923 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physiological variation in plasma total homocysteine concentrations in rats
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Hyperhomocysteinemia was initially related to cardiovascular diseases; but homocysteine (Hcy) metabolism disturbances have more recently associated with a wide range of pathophysiological conditions including age-related diseases, disrupted circadian rhythms and gynaecological disorders. Since in many cases we do not know to what extent animal models are physiologically similar to human ones, this study aimed to track spontaneous variations in rat plasma Hcy concentrations during different physiological processes such as life cycle, 24 hours and estrous cycle. Plasma total Hcy concentrations were accessed by HPLC. Plasma Hcy concentration varied with age and newborns had the lowest values (2.94 ± 0.47 μmol/L). Rats aged 10 days presented concentration similar to 3 month old animals (6.87 ± 0.67 and 8.29 ± 1.55 μmol/L respectively). Values decreased to 6.42 ± 1.65 μmol/L at 6 months and 4.87 ± 0.81 μmol/L at 28 months. Concerning circadian variations in Hcy concentration cosinor analysis showed acrophase in young rats at 1:09 pm, but no plasma Hcy circadian variations in aged rats. Female rats showed changes in Hcy concentration during the estrous cycle with higher values during the diestrous I (10.61 ± 1.81 μmol/L) compared with the estrous (8.47 ± 1.86 μmol/L) and diestrous II (7.68 ± 1.58 μmol/L) phases. In conclusion, plasma Hcy concentration varied spontaneously with ontogenic development and during the estrous cycle and presented a circadian rhythm variation in young rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 76, Issue 22, 15 April 2005, Pages 2621-2629
Journal: Life Sciences - Volume 76, Issue 22, 15 April 2005, Pages 2621-2629
نویسندگان
Paulo José Forcina Martins, Luciano Camargo Galdieri, Fernanda Gonçalves Souza, Monica Levy Andersen, Ana Amélia Benedito-Silva, Sergio Tufik, Vânia D'Almeida,