کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2554689 | 1124983 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of flavonols and their glycosides against free radical-induced oxidative hemolysis of red blood cells
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protective effects of flavonols and their glycosides against free radical-induced oxidative hemolysis of red blood cells Protective effects of flavonols and their glycosides against free radical-induced oxidative hemolysis of red blood cells](/preview/png/2554689.png)
چکیده انگلیسی
The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranoside (QG), quercetin rhamnopyranoside (QR), and kaempferol glucopyranoside (KG). The hemolysis of RBCs was induced by a water-soluble free radical initiator 2,2â²-azobis(2-methylpropionamidine) dihydrochloride (AAPH). It was found that addition of AAPH at 37 °C to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of FOHs significantly suppressed the hemolysis. The FOHs (MY, Q, R, QG and QR) which bears an ortho-dihydroxyl functionality showed much more effective anti-hemolysis activity than that of the other FOHs (MO, K and KG) bearing no such functionality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 78, Issue 21, 18 April 2006, Pages 2488-2493
Journal: Life Sciences - Volume 78, Issue 21, 18 April 2006, Pages 2488-2493
نویسندگان
Fang Dai, Qing Miao, Bo Zhou, Li Yang, Zhong-Li Liu,