کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2561927 1560844 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
چکیده انگلیسی

The notion that (poly)phenols act as direct free radical scavengers is being challenged by mere chemical and biochemical considerations such as bioavailability and intracellular concentrations. An alternative hypothesis that is gaining considerable traction is that (poly)phenols are processed by the body as xenobiotics via the Keap1/Nrf2/ARE signaling axis, leading to the induction of Phase II enzymes. However, there are no solid human data to confirm this interesting supposition. In this study, we tested the activities of hydroxytyrosol (HT) on Phase II enzymes’ expression in a double-blind, randomized, placebo-controlled study. We tested two HT doses, i.e. 5 and 25 mg/d, vs. placebo following a Latin square design. We report that HT is well tolerated but does not significantly modify Phase II enzyme expression in peripheral blood mononuclear cells. Moreover, we were unable to record significant effects on a variety of surrogate markers of cardiovascular disease such as lipid profile and inflammation and oxidation markers. Available evidence indicates that the “hormesis hypothesis” that (poly)phenols activate Phase II enzymes requires solid human confirmation that might be provided by future trials.This study is registered at ClinicalTrials.gov (identifier: NCT02273622).

Figure optionsDownload high-quality image (100 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volumes 95–96, May–June 2015, Pages 132–137
نویسندگان
, , , , , , ,