کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2562166 | 1127073 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice](/preview/png/2562166.png)
Clinical studies suggest that rosiglitazone (RSG) treatment may increase the incidence of heart failure in diabetic patients. In this study, we examined whether a high corn oil diet with RSG treatment in insulin resistant aging mice exerted metabolic and pro-inflammatory effects that stimulate cardiac dysfunction. We also evaluated whether fish oil attenuated these effects. Female C57BL/6J mice (13 months old) were divided into 5 groups: (1) lean control (LC), (2) corn oil, (3) fish oil, (4) corn oil + RSG and (5) fish oil + RSG. Mice fed a corn oil enriched diet and RSG developed hypertrophy of the left ventricle (LV) and decreased fractional shortening, despite a significant increase in total body lean mass. In contrast, LV hypertrophy was prevented in RSG treated mice fed a fish oil enriched diet. Importantly, hyperglycemia was controlled in both RSG groups. Further, fish oil + RSG decreased LV expression of atrial and brain natriuretic peptides, fibronectin and the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α, concomitant with increased interleukin-10 and adiponectin levels compared to the corn oil + RSG group. Fish oil + RSG treatment suppressed inflammation, increased serum adiponectin, and improved fractional shortening, attenuating the cardiac remodeling seen in the corn oil + RSG diet fed C57BL/6J insulin resistant aging mice. Our results suggest that RSG treatment has context-dependent effects on cardiac remodeling and serves a negative cardiac role when given with a corn oil enriched diet.
Proposed mechanism of the effect of chronic supplementation of a pro-inflammatory corn oil diet with rosiglitazone (RSG) on cardiac remodeling. RSG exacerbated pathological LV hypertrophy and dysfunction in aging C57BL/6J mice. When dietary corn oil was supplemented with fish oil, RSG exerted anti-inflammatory effects and prevented LV hypertrophy and dysfunction.Figure optionsDownload as PowerPoint slide
Journal: Pharmacological Research - Volume 63, Issue 4, April 2011, Pages 300–307