کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2562167 | 1127073 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties
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کلمات کلیدی
TNFαLPSDSSIL-LipopolyssacharideCOX-2TNBSICAM-1IBDDAIiNOSMCP-1MPO - DFORAW 264.7 cells - RAW 264.7 سلولTrinitrobenzenesulfonic acid - اسید Trinitrobenzenesulfonicinterleukin - اینترلوکینInflammatory bowel disease - بیماریهای التهابی رودهTetracycline - تتراسایکلینtumor necrosis factor α - تومور نکروز عامل αCaco-2 cells - سلول های Caco-2inducible nitric oxide synthase - سنتاز اکسید نیتریک القاییdextran sodium sulfate - سولفات سدیم سدیمCyclooxygenase-2 - سیکلوکوکسیژناز2disease activity index - شاخص فعالیت بیماریMetronidazole - مترونیدازولintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1myeloperoxidase - میلوپراکسیداز Minocycline - مینوسایکلینcytokine-induced neutrophil chemoattractant-1 - نوتروفیل شیمیایی ناشی از سیتوکین- 1Monocyte chemotactic protein-1 - پروتئین chemotactic monocyte-1CINC-1 - پنج-1Experimental colitis - کولیت تجربی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties](/preview/png/2562167.png)
چکیده انگلیسی
Some antibiotics, including minocycline, have recently been reported to display immunomodulatory properties in addition to their antimicrobial activity. The use of a compound with both immunomodulatory and antibacterial properties could be very interesting in the treatment of inflammatory bowel disease (IBD), so the aim of our study was to evaluate the anti-inflammatory effect of minocycline in several experimental models of IBD. Firstly, the immunomodulatory activity of the antibiotic was tested in vitro using Caco-2 intestinal epithelial cells and RAW 264.7 macrophages; minocycline was able to inhibit IL-8 and nitrite production, respectively. In vivo studies were performed in trinitrobenzenesulfonic acid (TNBS)-induced rat colitis and dextran sodium sulfate (DSS)-induced mouse colitis. The results revealed that minocycline exerted an intestinal anti-inflammatory effect when administered as a curative treatment in the TNBS model, modulating both immune and microbiological parameters, being confirmed in the DSS model; whereas none of the other antibiotics tested (tetracycline and metronidazole) showed anti-inflammatory effect. However, minocycline administration before the colitis induction was not able to prevent the development of the intestinal inflammation, thus showing that only its antimicrobial activity is not enough for the anti-inflammatory effect. In conclusion, minocycline displays an anti-inflammatory effect on different models of rodent colitis which could be attributed to the association of its antibacterial and immunomodulatory properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 63, Issue 4, April 2011, Pages 308-319
Journal: Pharmacological Research - Volume 63, Issue 4, April 2011, Pages 308-319
نویسندگان
Natividad Garrido-Mesa, Desirée Camuesco, Belén Arribas, Mònica Comalada, Elvira Bailón, Margarita Cueto-Sola, Pilar Utrilla, Ana Nieto, Antonio Zarzuelo, MarÃa Elena RodrÃguez-Cabezas, Julio Gálvez,