کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2563463 1127534 2011 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)
چکیده انگلیسی

Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors—VEGFs-, platet-derived growth factors—PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 129, Issue 1, January 2011, Pages 29–49
نویسندگان
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