کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2564892 1561047 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action
چکیده انگلیسی


• Curcumin reversed the CMS-induced behavioral abnormalities in rats.
• Curcumin inhibited cytokines in cerebral cortex and hippocampus.
• Curcumin reduced the activation of NF-κB.

Mounting evidence suggests that inflammation may contribute to the pathophysiology of depression. Curcumin, a polyphenol extracted from the plant Curcuma longa, exhibits a number of pharmacological properties, including potent anti-inflammatory action. Hence, the current study aimed to explore the immunomodulatory effects of curcumin in an animal model of chronic mild stress (CMS). Rats were subjected to CMS protocol for a period of 21 days to induce depressive-like behavior. The body weight, sucrose preference and locomotor activity were evaluated. Both RT-PCR and ELISA were used to determine the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the prefrontal cortex and hippocampus. Modulation of nuclear factor-κB (NF-κB) activation was assessed by western blotting. Chronic treatment with curcumin significantly reversed the CMS-induced behavioral abnormalities (reduced sucrose preference and decreased locomotor activity) in stressed rats. Additionally, curcumin effectively inhibited cytokine gene expression at both the mRNA and the protein level and reduced the activation of NF-κB. The study revealed that curcumin exerted antidepressant-like effects in CMS rats, partially due to its anti-inflammatory aptitude.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 47, 2 December 2013, Pages 33–39
نویسندگان
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