کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2564899 1561047 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sertraline and rapid eye movement sleep without atonia: An 8-week, open-label study of depressed patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Sertraline and rapid eye movement sleep without atonia: An 8-week, open-label study of depressed patients
چکیده انگلیسی


• Sertraline exacerbated Rapid eye movement (REM) sleep without atonia (RSWA).
• Sertraline-related RSWA have no predominance of male sex and elder age.
• Sertraline-related RSWA might have different mechanisms with idiopathic RBD.
• RSWA might be potential public health problem in the depressed patients.

Previous studies have reported that selective serotonin reuptake inhibitors (SSRIs) may induce or exacerbate rapid eye movement (REM) sleep without atonia (RSWA) and increase the risk of developing REM sleep behavior disorder (RBD). However, most of these studies are retrospective and cross-sectional and employed small sample sizes and a mixture of SSRIs. In this 8-week open-label trial of sertraline in depressed patients (n = 31), depressed patients were administered 50 mg sertraline at 8 am on the 1st day and subsequently titrated up to a maximum of 200 mg/day. All patients underwent repeated video-polysomnography (vPSG) (baseline, 1st day, 14th day, 28th day, and 56th day). Both tonic (submental) and phasic (submental and anterior tibialis) RSWA events were visually counted. Tonic RSWA increased from 3.2 ± 1.8% at baseline to 5.1 ± 2.3% on the 1st day and 10.4 ± 2.7% on the 14th day; after that, measurements were stable until the 56th day. A similar profile was observed for phasic RSWA. The increases in tonic RSWA (r = 0.56, P = 0.004) and phasic RSWA (submental: r = − 0.51, P = 0.02; anterior tibialis: r = 0.41, P = 0.04) were correlated with the degree of the prolonging of REM latency. All of RSWAs were not correlated with patients' demographic and clinical characteristics. Sertraline may induce or exacerbate RSWA. In contrast to idiopathic RBD, sertraline-related RSWA had the specific characteristics of being correlated with the degree of the prolonging of REM latency and no predominance of male sex and elder age, suggesting different pathophysiological mechanisms. The antidepressant-related RSWA should be a potential public health problem in the depressed patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 47, 2 December 2013, Pages 85–92
نویسندگان
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