Effects of ADORA2A gene variation and caffeine on prepulse inhibition: A multi-level risk model of anxiety

► An impact of the adenosine system on early information processing was proposed. ► Caffeine impaired prepulse facilitation in highly anxiety sensitive individuals ► Caffeine impaired information processing in female ADORA2A 1976TT homozygotes ► A multi-level risk-model of anxiety involving the adenosine system is suggested.