کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565229 | 1128053 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa
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کلمات کلیدی
catechol-O-methyltransferase geneDSM-IVCOMTEDICatechol-O-methyltransferaseAttention-Deficit/Hyperactivity Disorder - اختلال نقص توجه / بیش فعالیADHD - بیشفعالیval - ساعتbody mass index - شاخص توده بدنBMI - شاخص توده بدنیMethionine - متیونینMET - ملاقات کردEating Disorder Inventory - موجودی اختلالات خوردنHaplotype - هاپلوتیپValine - والینBulimia nervosa - پرخوری عصبیFamily control - کنترل خانوادهCase–control - کنترل مورد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa](/preview/png/2565229.png)
چکیده انگلیسی
⺠First study to assess transmission of COMT variants in BN probands and their first-degree relatives, as well as to explore the possible role of COMT functional genotypes and haplotypes as defined by Nackley et al. (2006) in BN. ⺠We observed preferential transmission for the A allele of rs6269, the T allele of rs4633, the C allele of rs4818, and the Met allele of rs4680 to the affected offspring with BN. ⺠The medium-activity COMT haplotype was significantly overtransmitted to the BN probands. ⺠BN cases and healthy controls did not differ in terms of COMT genotype and haplotype frequencies. ⺠The Val158 variant of COMT rs4680 was significantly overrepresented whereas the medium-activity haplotype was significantly underrepresented among BN probands with a history of childhood ADHD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 35, Issue 4, 1 June 2011, Pages 948-952
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 35, Issue 4, 1 June 2011, Pages 948-952
نویسندگان
Zeynep Yilmaz, Allan S. Kaplan, Clement C. Zai, Robert D. Levitan, James L. Kennedy,